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Using arti­fi­cial intel­li­gence and our metage­nomics exper­tise to explore nat­ur­al ecosys­tems, we recov­er nov­el cel­lu­lar sys­tems to devel­op cura­tive genet­ic med­i­cines. We use high-through­put screen­ing and arti­fi­cial intel­li­gence (“AI”) dri­ven algo­rithms to rapid­ly mine through bil­lions of nov­el pro­teins from the nat­ur­al world. This allows us to dis­cov­er genome edit­ing tools that are nat­u­ral­ly evolved to be high­ly effi­cient, spe­cif­ic, and targetable.

We have devel­oped an expan­sive and mod­u­lar tool­box of next-gen­er­a­­tion genome edit­ing sys­tems that will allow us to inter­act with the human genome in a site-spe­­cif­ic man­ner. Our com­pre­hen­sive genome edit­ing tool­box includes pro­gram­ma­ble nucle­as­es for gene knock-outs or knock-ins, base edi­tors for sin­gle base pair changes, and RNA- and DNA-medi­at­ed inte­gra­tion sys­tems for insert­ing or delet­ing large sec­tions of the human genome, includ­ing prime edit­ing sys­tems and CASTs, CRISPR-asso­ci­at­ed trans­posas­es. For a giv­en ther­a­peu­tic tar­get we aim to choose the ide­al gene edit­ing tool to pre­cise­ly cor­rect the human genome. 

We are tak­ing a step­wise approach deploy­ing our genome edit­ing tool­box to devel­op poten­tial­ly cura­tive ther­a­pies for patients. Our lead pro­grams are select­ed to both address dev­as­tat­ing dis­eases and to estab­lish new stan­dards in tar­getabil­i­ty, pre­ci­sion, effi­cien­cy, and scope of edit­ing capa­bil­i­ties. Metagenomi’s port­fo­lio of pro­grams aims to match the opti­mal genome edit­ing tool for each indi­ca­tion and cap­ture an ever-grow­ing set of trans­la­tion­al insights that inform and accel­er­ate future programs.